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Richard Kendall Selected Research

ganitumab

4/2014IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice.
1/2013Epitope-specific mechanisms of IGF1R inhibition by ganitumab.
6/2011Efficacy of ganitumab (AMG 479), alone and in combination with rapamycin, in Ewing's and osteogenic sarcoma models.
5/2009AMG 479, a fully human anti-insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells.

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Richard Kendall Research Topics

Disease

21Neoplasms (Cancer)
03/2017 - 11/2004
7Pain (Aches)
08/2021 - 11/2011
2Radiculopathy (Radiculopathy, Cervical)
10/2020 - 11/2011
2Osteoarthritis
11/2019 - 10/2013
2Breast Neoplasms (Breast Cancer)
11/2014 - 01/2009
1Low Back Pain (Lumbago)
01/2020
1Tendon Injuries
11/2019
1Melanoma (Melanoma, Malignant)
03/2017
1Pruritus (Itching)
01/2017
1Oncogene Addiction
01/2016
1Carcinoma (Carcinomatosis)
04/2014
1Weight Gain
04/2014
1Foreign Bodies (Foreign Body)
01/2014
1Hypersensitivity (Allergy)
01/2013
1Osteosarcoma (Osteogenic Sarcoma)
06/2011
1Sarcoma (Soft Tissue Sarcoma)
06/2011
1Corneal Neovascularization
10/2010
1Atrophy
10/2010
1Diabetic Retinopathy (Retinopathy, Diabetic)
10/2010
1Pancreatic Neoplasms (Pancreatic Cancer)
05/2009
1Glioblastoma (Glioblastoma Multiforme)
11/2007
1Body Weight (Weight, Body)
09/2006
1Burkitt Lymphoma (Burkitt's Lymphoma)
09/2003
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
09/2003
1Lymphoma (Lymphomas)
09/2003

Drug/Important Bio-Agent (IBA)

4SteroidsIBA
08/2021 - 11/2011
4Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
03/2017 - 02/2006
4Phosphotransferases (Kinase)IBA
01/2016 - 02/2007
4ganitumabIBA
04/2014 - 05/2009
3Insulin-Like Growth Factor I (IGF-1)IBA
01/2013 - 05/2009
3Monoclonal AntibodiesIBA
06/2011 - 02/2006
2AMG 337IBA
03/2017 - 01/2016
2Aurora KinasesIBA
07/2015 - 11/2014
2N- (4- ((3- (2- amino- 4- pyrimidinyl)- 2- pyridinyl)oxy)phenyl)- 4- (4- methyl- 2- thienyl)- 1- phthalazinamineIBA
07/2015 - 11/2014
2LigandsIBA
01/2015 - 01/2013
2Oxygen (Dioxygen)IBA
11/2014 - 10/2010
2Insulin ReceptorIBA
06/2011 - 05/2009
2Insulin-Like PeptidesIBA
06/2011 - 05/2009
2motesanib diphosphateIBA
01/2009 - 09/2006
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2009 - 09/2006
2Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
01/2009 - 09/2006
2Docetaxel (Taxotere)FDA Link
01/2009 - 11/2007
2Platelet-Derived Growth FactorIBA
01/2009 - 09/2006
2AntibodiesIBA
02/2007 - 02/2006
1Dexamethasone (Maxidex)FDA LinkGeneric
10/2020
1Triamcinolone (Aristocort)FDA Link
10/2020
1AnserineIBA
11/2019
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
03/2017
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
03/2017
1TabletsIBA
01/2017
12- (5- (3- chlorophenyl)- 6- (4- chlorophenyl)- 1- (1- (isopropylsulfonyl)- 3- methylbutan- 2- yl)- 3- methyl- 2- oxopiperidin- 3- yl)acetic acidIBA
03/2015
1Proto-Oncogene Proteins c-mdm2IBA
03/2015
1Histones (Histone)IBA
11/2014
1Bromodeoxyuridine (BrdU)IBA
11/2014
1Fluorouracil (Carac)FDA LinkGeneric
04/2014
1Glucose (Dextrose)FDA LinkGeneric
04/2014
1MetalsIBA
01/2014
1Insulin-Like Growth Factor II (Somatomedin A)IBA
01/2013
1Mechanistic Target of Rapamycin Complex 1IBA
06/2011
1Insulin (Novolin)FDA Link
06/2011
1TOR Serine-Threonine KinasesIBA
06/2011
1Glycogen Synthase (Synthase I)IBA
06/2011
1Sirolimus (Rapamycin)FDA Link
06/2011
1Hormones (Hormone)IBA
10/2010
1Retinaldehyde (Retinal)IBA
10/2010
1trebananibIBA
10/2010
1Angiopoietin-1IBA
10/2010
1Mitogen-Activated Protein KinasesIBA
08/2010
1Somatomedin Receptors (Somatomedin Receptor)IBA
05/2009
1GemcitabineFDA Link
05/2009
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
05/2009
1Phenobarbital (Luminal)FDA Link
01/2009
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
01/2009
1Doxorubicin (Adriamycin)FDA LinkGeneric
01/2009
1Estrogen Receptor Modulators (Antiestrogen)IBA
01/2009
1TamoxifenFDA LinkGeneric
01/2009
1rilotumumabIBA
11/2007
1Temozolomide (Temodar)FDA LinkGeneric
11/2007
1Peptides (Polypeptides)IBA
02/2007
1EpitopesIBA
02/2006
1Angiopoietin-2IBA
11/2004
1epratuzumabIBA
09/2003
1Immunoglobulin G (IgG)IBA
09/2003
1Rituximab (Mabthera)FDA Link
09/2003

Therapy/Procedure

4Therapeutics
03/2017 - 11/2004
3Radiofrequency Ablation
10/2020 - 11/2019
2Epidural Injections
08/2021 - 10/2020
2Catheters
08/2021 - 10/2020
2Drug Therapy (Chemotherapy)
03/2015 - 01/2009
1Aftercare (After-Treatment)
12/2020
1Lasers (Laser)
11/2014
1Oral Administration
11/2014
1Knee Replacement Arthroplasty (Total Knee Replacement)
10/2013
1Injections
11/2011